VPCS 317: General and Autonomic Pharmacology

General principles: Introduction to pharmacology and its relation to physiology and biochemistry.  Basic concepts; dose and drug dosage forms e.g. Injection, mixture, tablets. Routes of administration of drugs, factors guiding the choice of routes.  Advantage and disadvantage of various routes.  Pharmacokinetics-factors affecting absorption, distribution, biotransformation and excretion of drugs.  Enzyme induction and inhibition and implications.  General factors affecting drug action.  Targets for drug action-concept of receptors and drug receptor theories, enzymes, ion channels, carrier systems, Receptor super families.  Agonists, practical agonists and antagonists.  Drug antagonism and types-competitive versus non competitive, physiological and chemical.  Affinity, efficacy and potency defined.  DR relationships (Log DR versus DR curves) and significance of slope and shape of DR curves.

Autonomic pharmacology:  Somatic, efferent and ANS.  Parasympathetic and sympathetic, Ganglionic transmission, blockers, Transmitter processing at the cholinergic synapse. Sites for drug action.  Nomenclature for muscarinc receptors, agonists, antagonistic, effectors.

Adrenergic transmission.  Adrenergic receptor classification.  Pre-and post-functional sites for drug Uptake Metabolism and inhibitors.

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